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Isabel Cobham (née Spybie; 1750 – January 11, 1793) was the 6th great-grandmother of Cometan, classified as one of Cometan’s distant paternal ancestors in the Hardacre family line. Born in Croston in Lancashire, Isabel was the wife of Thomas Cobham. She is recorded as having died in Mawdesley in Lancashire. Isabel is the daughter of Robert Spybie and Elizabeth Pincock.
In Cometanic ancestry, Isabel is categorised as part of the 8th generation retrograde, classifying her as a distant ancestor of Cometan.